Multidisciplinary management of hepatocellular carcinoma
Lygidakis, N.J.; Tsiliakos, S.
Hepato-Gastroenterology 43(12): 1611-1619
1996
ISSN/ISBN: 0172-6390 PMID: 8975975 Document Number: 7174
Hepatocellular carcinoma (HCC) remains a disease with a poor prognosis. Several different therapies have been recommended for use as adjuvant treatment for this disease. One of the most promising therapies is targeted locoregional immuno-chemotherapy. From 1990 to 1996, 91 patients who were eligible for liver resection were treated in a prospective randomized study. Forty-two patients received resection alone (Group A) and 49 received resection plus chemoembolization and targeted locoregional immuno-chemotherapy (Group B). The mortality rate for these two groups was significantly different (13% vs 4%) favoring Group B. Overall survival was also significantly different (18 months vs 36.3 months) again favoring Group B. Although prognosis is still miserable for HCC, the approach of targeted locoregional immuno-chemotherapy can offer new hope of improved resectability and survival.
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