Local application of G-CSF, GM-CSF and EGF in treatment of wounds
Grzybowski, J.; Ołdak, E.; Janiak, M.K.
Postepy Higieny i Medycyny Doswiadczalnej 53(1): 75-86
1999
ISSN/ISBN: 0032-5449 PMID: 10352548 Document Number: 7090
G-CSF, GM-CSF and EGF play an important role in wound healing as components of the cytokine network which regulates cooperation of cells in the repair processes. The first two cytokines have been registered as hematopoietic drugs under the names Neupogen (Roche) and Leucomax (Sandoz). Both G-CSF and GM-CSF stimulate phagocytosis in maturated leucocytes and enhance proliferation of endothelial cells. G-CSF, GM-CSF and EGF which is known as mitogenic agent were applied as topical drugs for wound care; the application resulted in acceleration of wound healing. Preliminary suggestions as to the topical dosage of the cytokines in the treatment of wounds are put forward.
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