New approach in bioavailability study of two formulations of ethyl loflazepate
Ba, B.B.; Iliadis, A.; Durand, A.; Berger, Y.; Cano, J.P.
Arzneimittel-Forschung 38(10): 1486-1489
1988
ISSN/ISBN: 0004-4172 PMID: 2904268 Document Number: 704
The disposition of ethyl loflazepate (Victan) was studied on 12 healthy male volunteers after administration of the two oral formulations of the drug: one 4-mg tablet and two 2-mg tablets according to an open crossover single dose comparison. A model-independent analysis and a model-dependent approach were used to treat experimental data. Appropriate statistical tests (ANOVA, Wilcoxon test, Westlake test for model-independent parameters; principal components analysis, Hotelling T2 test for model-dependent parameters) demonstrated the bioequivalence of the two formulations.
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