Subacute thyroiditis and dyserythropoesis after influenza vaccination suggesting immune dysregulation
Hernán Martinez, J.; Corder, E.; Uzcategui, M.; Garcia, M.; Sostre, S.; Garcia, A.
Boletin de la Asociacion Medica de Puerto Rico 103(2): 48-52
2011
ISSN/ISBN: 0004-4849 PMID: 22111471 Document Number: 702618
Subacute thyroiditis (SAT) is an extremely rare complication of influenza vaccination. Several infectious agents have been related with SAT. It is also well known the association between HLA-B35 and the development of SAT. We describe a case of subacute thyroiditis and dyserythropoesis occurring shortly after administration of an influenza vaccine in a 55-year-old man with history of diabetes and psoriasis, family history of autoimmunity without clinical evidence of acute viral infection prior to the onset of symptoms. We propose that, the events occurring in the patient may be explained as result of complex interactions between the individual genetic background and environmental exposure to infectious agents that generated a pro-inflammatory status, where the vaccine was the trigger for the subsequent alterations in thyroid and bone marrow. These findings highlight the importance of immunogenetic factors involved in response to vaccination that is the central theme in the growing field of 'vaccinomics'.