Precocious sexual development: clinical study in the western region of Puerto Rico
Pérez Comas, A.
Boletin de la Asociacion Medica de Puerto Rico 74(9): 245-251
1982
ISSN/ISBN: 0004-4849 PMID: 6963911 Document Number: 701313
Precocious sexual development may manifest in complete form (true precocious puberty and pseudoprecocious puberty) and as an incomplete form as seen in premature breast development (thelarche) and secondary sexual ha ir (adrenarche or pubarche). Any manifestation prior to 8 years of age is abnormal and merits adequate evaluation. This anide summarizes our clinical experience in the evaluation of 272 patients during the last 10 years. An increase in pituitary gonadotropins (FSH-LH), ovarian hormones (total estrogens) and prolactin is documented in multiple patients as detailed in the text and is correlated with the diagnosis of premature thelarche, precocious puberty and premature adrenarche. Distribution by town in the western region of Puerto Rico is studied, the age of onset, as well as the month and year of onset of symptoms. A significant increase of the conditions was observed for 1975, 1978-79, and 1980; being the latter the highest year of premature thelarche and 1979 the highest for precocious puberty cases. The importance of clinical and epidemiological studies is emphasized.
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