Double-blind study of lecithin in the treatment of persistent tardive dyskinesia
Pérez-Cruet, J.; Menéndez, I.; Alvarez-Ghersi, J.; Falcón, J.R.; Valderrábano, O.; Castro-Urrutia, E.C.; Ifarraguerri, C.; Pérez, L.L.
Boletin de la Asociacion Medica de Puerto Rico 73(11): 531-537
1981
ISSN/ISBN: 0004-4849 PMID: 6121562 Document Number: 701037
Lecithin, a natural precursor of choline and acetylcholine has been found to be of benefit in treating tardive dyskinesia (TD). A disturbance in the balance between a hypofunctioning cholinergic system and a hyperfunctioning dopaminergic system has been postulated as the pathophysiology of this involuntary movement disorder. For this reason the lecithin as a precursor of choline and acetylcholine should correct the hypofunctioning of the cholinergic system and presumably correct the putative neurotransmitter imbalance. The present double-blind study was done in four patients with persistent tardive dyskinesia free from drugs for at least 2 to 3 months prior to the treatment with lecithin. It was found that lecithin diminished the involuntary movements but did not produce a complete cure of the abnormal movements.
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