Phenytoin induced fatal hepatic injury
Carro, J.A.; Senior, J.; Rubio, C.E.; Torres, E.A.
Boletin de la Asociacion Medica de Puerto Rico 81(9): 359-360
1989
ISSN/ISBN: 0004-4849 PMID: 2818777 Document Number: 700605
A 61 year old female developed fatal hepatic failure after phenytoin administration. A typical multisystem clinical pattern precedes the manifestations of hepatic injury. The hematologic, biochemical and pathologic features indicate a mixed hepatocellular damage due to drug hypersensitivity. In a patient receiving phenytoin who presents a viral-like illness, early recognition and discontinuation of the drug are mandatory.
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