Progress in the Mechanism and Clinical Application of Cilostazol
Zheng, H.; Yang, H.; Gong, D.; Mai, L.; Qiu, X.; Chen, L.; Su, X.; Wei, R.; Zeng, Z.
Current Topics in Medicinal Chemistry 19(31): 2919-2936
2019
ISSN/ISBN: 1568-0266 PMID: 31763974 Document Number: 699675
Cilostazol is a unique platelet inhibitor that has been used clinically for more than 20 years. As a phosphodiesterase type III inhibitor, cilostazol is capable of reversible inhibition of platelet aggregation and vasodilation, has antiproliferative effects, and is widely used in the treatment of peripheral arterial disease, cerebrovascular disease, percutaneous coronary intervention, etc. This article briefly reviews the pharmacological mechanisms and clinical application of cilostazol.