Two-way relationship between diabetes and periodontal disease: a reality or a paradigm?
Oberti, L.; Gabrione, F.; Nardone, M.; Di Girolamo, M.
Journal of Biological Regulators and Homeostatic Agents 33(3 Part 1): 153-159. Dental Suppl
2019
ISSN/ISBN: 0393-974X PMID: 31538462 Document Number: 699626
Diabetes mellitus (DM) and periodontal disease (PD) are both chronic diseases. From one side, DM have an adverse effect on PD, and on the other side PD may influence DM. Systemic therapy of DM with glycaemic control, affects the progress of PD. Reversely treatment of PD combined with the administration of systemic antibiotics seems to have a double effect on diabetic patients reducing the periodontal infection and improving the glycaemic control. Inflammation, altered host responses, altered tissue homeostasis are common characteristic of both DM and PD. The potential common pathophysiologic pathways of direct or reverse relationship of DM and PD are still unknown and further in vitro and in vivo studies are needed to explore this relationship.