Diagnostic performance of anti-RA33 antibody as a serological marker for rheumatoid arthritis
Syed Mohamed Suhail, S.M.; Nur Atiqah, I.; Nur Salimi Zakirah, Z.A.; Lailatul Syazwani, Z.; Batis, W.W.; Md Monoto, E.M.; Abdul Wahab, A.; Mohd Shahrir, M.S.
Malaysian Journal of Pathology 41(3): 259-265
2019
ISSN/ISBN: 0126-8635 PMID: 31901910 Document Number: 698891
Rheumatoid arthritis is diagnosed based on the 2010 Rheumatoid Arthritis Classification Criteria whereby rheumatoid factor and anti-citrullinated protein antibody are the serological markers included in these criteria. Anti-RA33 antibody has the potential to provide additional diagnostic value in rheumatoid arthritis. The aim of this study is to determine the diagnostic performance of anti-RA33 antibody as a serological marker for rheumatoid arthritis. Thirtyfour patients with rheumatoid arthritis and 34 non-rheumatoid arthritis individuals were included in this cross-sectional study. Anti-RA33 antibody and rheumatoid factor were performed on all samples. The sensitivity, specificity, positive and negative predictive value for anti-RA33 antibody and rheumatoid factor were 41.1%, 97.1%, 93.3%, 62.3% and 64.7%, 79.4%, 75.9%, 69.2% respectively. The overall sensitivity and specificity if either anti-RA33 antibody or rheumatoid factor are positive were 79.4% and 76.47% respectively. Anti-RA33 antibody showed good specificity and positive predictive value and could be considered as a potential serological marker for rheumatoid arthritis diagnosis.