Application of polygenic risk scores in risk prediction and precision prevention of complex diseases: opportunities and challenges
Hang, D.; Shen, H.B.
Zhonghua Liu Xing Bing Xue Za Zhi 40(9): 1027-1030
2019
ISSN/ISBN: 0254-6450 PMID: 31594139 Document Number: 698881
随着人类基因组学研究的飞跃发展，全基因组关联研究已成功鉴定出大量复杂性疾病的易感位点。多基因风险评分通过综合多个易感位点信息预测疾病风险，在人群风险预测、优化筛查方案、实施精准预防等方面初显应用价值。本研究就多基因风险评分的最新进展作一概述，总结其应用机遇和挑战。.
Document emailed within 1 workday
Related Documents
Bolsin, S.N. 1997: Risk prediction in coronary artery surgery: a comparison of four risk scores Medical Journal of Australia 167(7): 397; 400MacKellar, D.A.; Valleroy, L.A.; Secura, G.M.; Behel, S.; Bingham, T.; Celentano, D.D.; Koblin, B.A.; Lalota, M.; McFarland, W.; Shehan, D.; Thiede, H.; Torian, L.V.; Janssen, R.S. 2005: Unrecognized HIV infection, risk behaviors, and perceptions of risk among young men who have sex with men: opportunities for advancing HIV prevention in the third decade of HIV/AIDS Journal of Acquired Immune Deficiency Syndromes 38(5): 603-614
Sugavanam, B. 1996: Risk reduction in pesticide development in developing countries: Challenges and opportunities Journal of Environmental Science and Health Part B Pesticides Food Contaminants and Agricultural Wastes 31(3): 307-323
Von Meijenfeldt, G.C.I.; Van Der Laan, M.J.; Zeebregts, C.J.; Balm, R.; Verhagen, H.J.M. 2016: Risk assessment and risk scores in the management of aortic aneurysms Journal of Cardiovascular Surgery 57(2): 162-171
Kelly, R.B.; Acheson, L.S.; Zyzanski, S.J. 1988: Comparison of three prenatal risk scores in a series of low-risk pregnancies Family Medicine 20(2): 122-127
1997: Science and Health: Opportunities and Challenges for the 21th Century. Control and prevention of infectious diseases: emerging and re-emerging. Report of Working Group 4 Southeast Asian Journal of Tropical Medicine and Public Health 28(Suppl 2): 192
Bellomo, A.; Mancinella, M.; Troisi, G.; Marigliano, V. 2009: Relationship between atrial fibrillation and other cardiovascular risk factors in Alzheimer's disease. New prevention opportunities Recenti Progressi in Medicina 100(3): 124-126
Swartzell, K.L.; Fulton, J.S.; Friesth, B.M. 2013: Relationship between occurrence of falls and fall-risk scores in an acute care setting using the Hendrich Ii fall risk model Medsurg Nursing: Official Journal of the Academy of Medical-Surgical Nurses 22(3): 180-187
Osler, M.; Jespersen, N.B.; Lous, J.; Rasmussen, N.K. 1992: Cardiovascular risk factors--extent and self-assessed risk in relation to prevention of cardiovascular diseases. A questionnaire among 3,956 men and women aged 24-65 years in Vejle County, Slangerup and Helsinge municipalities Ugeskrift for Laeger 154(9): 538-543
Grossarth-Maticek, R.; Vetter, H.; Frentzel-Beyme, R.; Heller, W.D. 1988: Precursor lesions of the GI tract and psychosocial risk factors for prediction and prevention of gastric cancer Cancer Detection and Prevention 13(1): 23-29
Stamler, J. 1973: Heart disease prevention in industry. Primary prevention in mass community efforts to control the major coronary risk factors: the challenges and possibilities--critical issues and outlook for the future Journal of Occupational Medicine.: Official Publication of the Industrial Medical Association 15(1): 54-59
Sahu, A.; Gupta, T.; Kavishwar, A.; Singh, R.K. 2015: Cardiovascular Diseases Risk Prediction by Homocysteine in Comparison to other Markers: A Study from Madhya Pradesh Journal of the Association of Physicians of India 63(10): 37-40
Geary, C.W.; Bukusi, E.A. 2014: Women and ARV-based HIV prevention - challenges and opportunities Journal of the International Aids Society 17(3 Suppl. 2): 19356
Bonow, R.O. 2004: Prevention of cardiovascular disease: challenges and opportunities Italian Heart Journal: Official Journal of the Italian Federation of Cardiology 5 Suppl. 6: 6s-8s
Peresun'ko, O.P.; Cheban, V.I. 2003: Clinical criteria of the risk of oncological diseases in women as a basis for prevention of reproductive system diseases Likars'ka Sprava 2003(3-4): 60-63
Vrhovski, D.; Mestrić, Z.; Subić, N.; Surina, B.; Kranjcević, S. 1985: Established risk factors and complementary risk factors as additional parameters in evaluating the risk of cardiovascular diseases Lijecnicki Vjesnik 107(11-12): 481-484
von Felten, A. 1992: Prevention of venous thromboembolism with heparin in risk patients during pregnancy: monitoring by measuring thrombin-antithrombin III complex Therapeutische Umschau. Revue Therapeutique 49(12): 837-842
Meister, W. 1989: Risk factors and prevention of cardiovascular diseases Der Internist 30(5): 276-282
Gay, C.G.; Salt, J.; Balaski, C. 2003: Challenges and opportunities in developing and marketing vaccines for OIE List A and emerging animal diseases Developments in Biologicals 114: 243-250
Kim, Y-Mi.; Lambe, F.Maria.; Soetikno, D.; Wysong, M.; Tergas, A.Isabel.; Rajbhandari, P.; Ati, A.; Lu, E. 2013: Evaluation of a 5-year cervical cancer prevention project in Indonesia: opportunities, issues, and challenges Journal of Obstetrics and Gynaecology Research 39(6): 1190-1199