Anti-Angiogenesis Therapy in Ovarian Cancer: which Patient is it Most Likely to Benefit?
Chelariu-Raicu, A.; Coleman, R.L.; Sood, A.K.
Oncology 33(7)
2019
ISSN/ISBN: 0890-9091 PMID: 31365748 Document Number: 698092
Angiogenesis is known to play an important role in normal ovarian physiology as well as in growth and progression of ovarian cancer. The first FDA approval of bevacizumab in 2004 was for metastatic colorectal cancer in combination with chemotherapy; this was a key point for several subsequent approvals of antiangiogenic drugs. The efficacy of bevacizumab treatment is modest, however, and most ovarian cancer patients eventually develop acquired resistance, which highlights the need for new targeted therapies and/or combination strategies. Understanding the multitude of variables in response to antiangiogenic therapy would offer potential strategies for selecting patients most likely to benefit from such therapy.