Association between dyslipidemia and carotid plaque incidence in a research group: a prospective cohort study
Liu, J.; Ma, X.H.; Yan, L.Y.; Liu, M.; Wang, S.S.; He, Y.
Zhonghua Liu Xing Bing Xue Za Zhi 40(3): 341-345
2019
ISSN/ISBN: 0254-6450 PMID: 30884615 Document Number: 697864
目的: 探讨基线血脂异常与颈动脉斑块发病风险的关联及其强度。 方法: 本研究为前瞻性队列研究。2017年对参加2010年基线调查的解放军第三○四医院健康体检的716名科研工作者开展随访调查,随访结局为颈动脉斑块发生。 结果: 基线716名非颈动脉斑块人群经8年随访,共发生颈动脉斑块289例,累计发病率为40.36%。拟合Cox比例风险模型,在调整了年龄、性别、BMI、腰围、SBP、DBP、ALT、FPG和尿酸后,以无血脂异常组为对照组,该职业人群患有≥3种血脂异常组发生颈动脉斑块风险升高68.1%(HR=1.681,95%CI:1.090~2.593)。 结论: 血脂异常与颈动脉斑块发生相关,有≥3种血脂异常人群的颈动脉斑块发病风险升高,防止血脂异常或减少血脂异常的种类可能是预防和控制颈动脉斑块形成的有效措施之一。.
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