Treatment Outcomes of Curative Resection for Colorectal Cancer with Synchronous Liver Metastasis
Yokomizo, H.; Okayama, S.; Yamada, Y.; Maeda, H.; Ida, A.; Satake, M.; Yano, Y.; Asaka, S.; Usui, T.; Shiozawa, S.; Yoshimatsu, K.; Shimakawa, T.; Katsube, T.; Kato, H.; Naritaka, Y.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 45(13): 2249-2251
2018
ISSN/ISBN: 0385-0684 PMID: 30692347 Document Number: 697650
The aim of this study was to clarify prognosis for curative resection performed for cases of colorectal cancer with synchronous liver metastasis and to use the findings as future treatment indices. Subjects comprised 61 patients who underwent curative resection at our hospital for colorectal cancer accompanied by synchronous liver metastasis between 1996 and 2014. The degree of liver metastasis was H1 for 47 cases and H2 for 14 cases. The Grade of liver metastasis was A for 29 cases, B for 18 cases, and C for 14 cases. Liver resection was performed simultaneously with that of the primary lesion for 33 cases, and after that of the primary lesion for 28 cases. The post-curative resection survival period was 58.0 months, and the 5-year survival rate was 49.9%. In terms of the relationship between prognosis and clinicopathological factors, prognosis was found to be poor when the wall depth of the primary lesion was pT4 and when the liver metastasis Grade was B or C. Meanwhile, prognosis did not differ depending on the timing of liver metastasis resection, whether chemotherapy was performed after liver resection, and whether curative resection was performed for initial occurrence only or recurrence resection was performed. The results indicated that for cases of colorectal cancer with synchronous liver metastasis, primary lesion wall depth and liver metastasis Grade were prognostic factors, and that the treatment strategy did not necessarily have to consider resection timing.