Effectiveness of intralesional steroid injections with dilatation in corrosive oesophageal strictures - a Randomized Control Trial
Randhawa, F.A.; Butt, N.F.; Talat, S.O.; Sabir, S.H.; Qamar, M.A.
JPMA. Journal of the Pakistan Medical Association 68(11): 1556-1559
2018
ISSN/ISBN: 0030-9982 PMID: 30410128 Document Number: 697630
To compare the improvement of dilatation among patients receiving intralesional steroid injection with dilatation versus dilatation alone for the management of corrosive ooesophageal strictures. The randomized controlled trial was conducted at Mayo Hospital, Lahore, Pakistan, from November 10, 2014, to November 10, 2015, and comprised patients of either gender aged 15-50years who had corrosive ooesophageal stricture. They were randomised into 2 groups by using the lottery method. In the dilatation group, only endoscopic dilation was done, while in the combination group, intralesional triamcinolone injection was injected followed by dilatation. Follow-up endoscopic dilatation was done every two weeks. Data was analysed using SPSS 21. There were 60 patients randomised into two groups of 30(50%) each. The overall mean age was 32.58±10.58 years and the male-to-female ratio was 1.7:1. At baseline, in dilatation group, the mean stricture length was 23.30±2.28cm while in combination group, it was 24.23±3.06cm. In dilatation group, the mean stricture length was 11.20±3.09cm while in combination group, it was 5.33±3.09cm (p=0.0001).. oesophageal Combination group was more effective than the dilatation-alone group.