Association of Non-HDL Cholesterol, Homocysteine and Vitamin D in Acute Coronary Syndrome
Bahulikar, A.; Tickoo, V.; Phalgune, D.
Journal of the Association of Physicians of India 66(8): 22-25
2018
ISSN/ISBN: 0004-5772 PMID: 31324079 Document Number: 697560
The role of Low Density Lipoprotein Cholesterol (LDL-C) in the pathogenesis of Coronary Heart Disease (CHD) has been well established. In many studies it was found that Non-HDL cholesterol (total cholesterol minus High Density Lipoprotein Cholesterol [HDL-C] is a better predictor of CHD risk than LDL-C alone. High homocysteine levels are associated with increased risk of cardiovascular and cerebrovascular disease. An inverse relation has been seen between vitamin D serum level and coronary artery calcification. Studies are inadequate among Indians to establish the role of these non-conventional risk factors in acute coronary syndrome. To correlate the values of non-HDL cholesterol, vitamin D and homocysteine in patients with acute coronary syndrome (ACS) with controls. :For this retrospective study cases were the patients admitted in Poona Hospital and Research Centre between November 2013 and November 2015 with acute coronary syndrome whereas controls were patients admitted in Poona Hospital and Research Centre during the same period with diagnosis other than Acute coronary syndrome. Each patient was subjected to detailed clinical history, clinical examination and investigations such as lipid profile, serum homocysteine, and Vitamin D3. Unpaired t-test was used to compare the quantitative data whereas Chi-square test or Fisher's exact test was used for qualitative data. ACS group had significantly higher mean total serum cholesterol, mean LDL cholesterol, mean non-HDL cholesterol, and mean plasma homocysteine as compared to control group. However, there was no statistically significant difference between the two groups in Vit D levels. Odds ratio was maximum for Non HDL cholesterol, followed by LDL cholesterol, HDL cholesterol, Serum Homocysteine, and Total cholesterol. Non-HDL cholesterol was a better predictor of cardiovascular diseases than LDL-C, HDL-C or total cholesterol.