Protein carbamylation: what it is and why it concerns nephrologists
De Simone, E.; Di Micco, L.; La Manna, G.; Di Iorio, B.
Giornale Italiano di Nefrologia: Organo Ufficiale Della Societa Italiana di Nefrologia 35(3)
2018
ISSN/ISBN: 1724-5990 PMID: 29786184 Document Number: 697538
Spontaneous urea dissociation in water solution is a prominent source of protein carbamylation in our body. Protein carbamylation is a well-known phenomenon since early seventies. Some years ago, much interest in the diagnostic power of carbamylated protein arouse. Recently the target of the researches focused on its potential cardiovascular pathogenicity. Some authors claimed that this could be a reason for higher cardiovascular mortality in uremic patients. Nutritional therapy, amino acids supplementation and intensive dialysis regimen are some of the therapeutic tools tested to lower the carbamylation burst in this population.