Effects of Immune Checkpoint Inhibitor Combined with Dendritic Cell Therapy and Hyperthermia
Takeda, T.; Kubota, Y.; Takeda, T.; Tanaka, C.; Morita, S.; Hattori, N.; Takeda, H.; Yokoyama, Y.; Yamamoto, H.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 45(10): 1472-1474
2018
ISSN/ISBN: 0385-0684 PMID: 30382049 Document Number: 696777
In this study, 97cancer patients were treated with combined immune checkpoint inhibitor therapy and dendritic cell thera- py between June 2015 and April 2018. We administered nivolumab with 2-3mg/kg bw every 2-3weeks. The rate of progress in cases where nivolumab was administered more than 3 times was 55.2%. Dendritic cell therapy enhanced the immune checkpoint inhibitor therapy. In cases where the effect of combined immune checkpoint inhibitor therapy and dendritic cell therapy was restricted, hyperthermia and radiation therapy are useful for the recovery of combined therapy.