Clinical Efficiency of Cycloferon in Children and Adults with HIV And/ or Herpes Infection: Systematic Review and Meta-Analysis
Mazina, N.; Mazin, P.; Kovalenko, A.
Georgian Medical News 282: 121-129
2018
ISSN/ISBN: 1512-0112 PMID: 30358555 Document Number: 695300
Aim was to estimate and compare clinical efficiency of cycloferon use against basic therapy in treatment of HIV and/ or herpes infection. There were comparisons of treatment results with patient (n=1274) groups' heterogeneity taken into account. 9 randomized clinical trials with cycloferon efficacy data were mobilized, in all studies there were protocols of injections, tablets or liniments cycloferon administration. Homogeneous and symmetric groups combination during meta-analysis increased statistic power of comparisons and led to integrative efficiency assessment, proved its' stability in statistic models. Cycloferon use in children and adults with HIV and/ or herpes infection was more the 3 times more effective to provide stable remission and exacerbation frequency diminish against basic therapy.