Contributions of VSX1 gene to keratoconus
Kalasidou, G.; Frydas, I.; Kozei, A.; Syrmakesi, P.; Loukovitis, E.; Sfakianakis, K.; Balidis, M.; Zachariadis, Z.; Tranos, P.; Kozeis, N.; Anogeianakis, G.
Journal of Biological Regulators and Homeostatic Agents 32(6): 1515-1518
2018
ISSN/ISBN: 0393-974X PMID: 30574758 Document Number: 695126
Keratoconus (KC) is a complex, genetically heterogeneous, multifactorial degenerative corneal disorder, with incidence of approximately 1 per 2000 of the population. KC follows an autosomal recessive or dominant pattern of inheritance and is, apparently, associated with genes which interact with environmental, genetic and/or other factors. The present report focuses on the VSX1 gene, for which there is general agreement that it is involved in KC and other corneal pathologies, and critically details the evidence for its involvement in KC.