Prognostic value of Ki67: comparison of the proliferation index between meningiomas with and without infiltration of glial tissue
Zehani, A.; Chelly, I.; Haouet, S.; Kchir, N.
La Tunisie Medicale 95(7): 466-470
2017
ISSN/ISBN: 0041-4131 PMID: 29694649 Document Number: 693907
Although generally considered benign, meningiomas can cause significant morbidity and mortality. Histologic grade is the most useful morphologic predictor of recurrence. To compare Ki67 labeling index between meningioma grade I and meningioma grade II with brain invasion. We analyzed 20 primary meningioma, 10 of which were grade I and 10 of which were grade II. Ki67 proliferative indices were determined in all cases. The patient population consisted of 9 males and 11 females with mean age of 60 years. For meningioma grade I, the Ki67 labeling index varied between 1 and 15% with an average of 3.1%. A diagnosis of gradeII meningiomas was made solely on the basis of brain invasion. The immunohistochemical study noted that the Ki67 index varied between 1 and 20% with an average of 6,8%. The Ki67 labeling index shows a significant increase from grade I to grade II. It may provide useful prognostic information.
Document emailed within 1 workday
