Role of adiponectin in prostate cancer: a preliminary study
Fu, S.; Xu, H.; Liu, C.; Gu, M.; Wang, Q.; Zhou, J.; Wang, Z.
Zhonghua Nan Ke Xue 23(11): 975-981
2017
ISSN/ISBN: 1009-3591 PMID: 29738161 Document Number: 693850
目的： 研究血清脂联素水平与前列腺癌发生的关系以及脂联素对前列腺癌细胞生物学特性的影响。方法： 采用病例对照试验回顾性分析45例前列腺癌患者(病例组)和50例非前列腺癌患者(对照组)血清脂联素水平和前列腺癌发生之间的关系。利用慢病毒载体构建脂联素受体缺陷的稳转细胞株，用脂联素干预前列腺癌细胞系并通过CCK-8实验、流式细胞实验、成管实验和划痕实验分析脂联素作用升高和降低对PC3细胞生物学行为的影响。结果： 与对照组患者［(6.35±4.43) μg/ml］比较，病例组血清脂联素水平［(3.49±2.70) μg/ml］降低，并且脂联素水平与Gleason评分高低呈负相关(r=－0.504, P<0.01)。脂联素抑制PC3细胞的增殖，迁移，抑制细胞进入S期，并抑制血管形成，而在脂联素受体缺陷的情况下，PC3细胞反而具有更强的增殖、迁移和促血管形成能力。结论： 血清脂联素下降或脂联素受体缺陷可能是促进前列腺癌发生的因素。.
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