Recent perspectives of ependymomas (childhood brain tumors)
Zeng, Z-D.; Liu, F-L.; Li, S-X.
European Review for Medical and Pharmacological Sciences 21(4 Suppl): 13-19
2017
ISSN/ISBN: 1128-3602 PMID: 29165771 Document Number: 692609
Ependymomas are childhood brain tumors that occur throughout the central nervous system, but are most common in the hindbrain, also known as the posterior fossa (PF). Current standard therapy comprises maximal safe surgery, and there is no scope for further increase in survival. Despite the histological similarity, ependymomas from throughout the neuroaxis likely comprise multiple independent entities, each with a distinct molecular pathogenesis. The present review article would discuss both genetics and epigenetics of ependymomas.