The prevalence of human papillomaviruses in patients with colon polyps
Mlynarczyk-Bonikowska, B.; Muszyński, J.; Szymanek-Mjchrzak, K.; Ziółowski, B.; Mlynarczyk, G.; Malejczyk, M.; Majewski, L.
Medycyna Doswiadczalna i Mikrobiologia 69(1): 49-54
2017
ISSN/ISBN: 0025-8601 PMID: 30351624 Document Number: 691778
Potential role of HPV infection in pathogenesis of colon polyps and cancer remains undetermined. The aim of the study was to investigate the prevalence of DNA of HPV- 6, -11, -16 and -18 in the biopsies from colon polyps. We investigated the biopsies from 24 patients (23 from colon polyps and I from colon cancer) of Department of Gastroenterology Medical University of Warsaw using Real time PCR HPV-6/11. Real-TM (Sacace Biotechnologies) was performed on termocycler Smart Cycler Dx. We didn't detect oncogenic HPV16 and HPV18 in any of the investigated specimens, HPV-11 was present in 11 patients including all patients with adenoma tubule-villosum. We detect HPV6 in 5 samples from polyps and 1 from colon cancer. HPV 6 and HPV 11 could play a role in pathogenesis some colon polyps but the final conclusions demand further investigations. Oncogenic HPV 16 and 18 probably don't play any role in colon polyps pathogenesis.