Active surveillance of adverse drug reaction in the era of big data: challenge and opportunity for control selection
Wang, S.F.; Zhan, S.Y.
Zhonghua Liu Xing Bing Xue Za Zhi 37(7): 909-916
2016
ISSN/ISBN: 0254-6450 PMID: 27453095 Document Number: 691418
Electronic healthcare databases have become an important source for active surveillance of drug safety in the era of big data. The traditional epidemiology research designs are needed to confirm the association between drug use and adverse events based on these datasets, and the selection of the comparative control is essential to each design. This article aims to explain the principle and application of each type of control selection, introduce the methods and parameters for method comparison, and describe the latest achievements in the batch processing of control selection, which would provide important methodological reference for the use of electronic healthcare databases to conduct post-marketing drug safety surveillance in China.