Autologous bone marrow concentrate combined with platelet-rich plasma enhance bone allograft potential to induce spinal fusion
Vadalà, G.; Di Martino, A.; Russo, F.; Tirindelli, M.C.; De Felice, L.; Agostini, F.; Papalia, R.; Denaro, V.
Journal of Biological Regulators and Homeostatic Agents 30(4 Suppl 1: 165-172
2016
ISSN/ISBN: 0393-974X PMID: 28002915 Document Number: 691119
Bone marrow cells concentrate (BMCs) is a source of osteoprogenitor cells and platelet-rich plasma (PRP) is a source of growth factors. The objective of the study was to determine whether BMC and PRP could increase the potential of bone allograft to induce posterolateral-lumbar spinal fusion compared to the bone allograft alone. A prospective nonrandomized radiographic study has been conduced on 10 patients with posterolateral instrumented fusion for degenerative lumbar disease with 1-year follow-up using CT scan. A fresh frozen bone allograft alone and bone allograft with a mixture of autologous BMC and PRP blended with thrombin were apposed in the right and left posterolateral side, respectively. CT showed good right fusion masses (allograft alone) in 4 patients and poor in 6; good left masses (BMC and PRP plus allograft) in 9 patients and poor in 1. The differences detected between right-side and left-side masses show an advantage in adding BMC and PRP to the bone allograft to increase spinal fusion rate.