Positive expression of insulin-like growth factor-1 receptor is associated with a positive hormone receptor status in ovarian cancer
Wang, L.Q.; Zhao, W.D.; Jiao, X.J.; Du, D.L.; Liu, Y.S.
European Journal of Gynaecological Oncology 37(2): 204-210
2016
ISSN/ISBN: 0392-2936 PMID: 27172746 Document Number: 691049
Summary Ovarian cancer is the most deadly of all gynecologic malignancies, due in part to the diagnosis at an advanced stage caused by the deficiency of specific marks and symptoms, by the absence of reliable tests for screening, and by early detection. Insulin-like growth factor-I (IGF-I) is known to be involved in the development and promotion of diverse examples of solid tumors including ovarian cancer. IGF-I levels in local tissue are subject to both endocrine and paracrine/autocrine regulation. Most patients will react initially to treatment, but almost 70% of them will have a recurrence. Consequently, new therapeutic modalities are urgently required to overcome chemoresistance observed in ovarian cancer patients. IGF-1R expression was evaluated immunohistochemically in tissue microarray blocks constructed from 1,200 ovarian cancer samples collected from three medical institutions. Evidence accumulates suggesting that the insulin/insulin growth factor (IGF) pathways could play a good therapeutic target in various cancers, including ovarian cancer.