HPV vaccination impact on a cervical cancer screening program: methods of the FASTER-Tlalpan Study in Mexico
Salmerón, J.; Torres-Ibarra, L.; Bosch, F.Xavier.; Cuzick, J.; Lörincz, A.; Wheeler, C.M.; Castle, P.E.; Robles, C.; Lazcano-Ponce, E.
Salud Publica de Mexico 58(2): 211-219
2016
ISSN/ISBN: 0036-3634 PMID: 27557379 Document Number: 690804
To outline the design of a clinical trial to evaluate the impact of HPV vaccination as part of a hrHPV-based primary screening program to extend screening intervals. A total of 18,000 women aged 25-45 years, attending the regular cervical cancer-screening program in primary health care services in Tlalpan, Mexico City, will be invited to the study. Eligible participants will be assigned to one of three comparison groups: 1) HPV16/18 vaccine and hrHPV-based screening; 2) HPV6/11/16/18 vaccine and hrHPV-based screening; 3) Control group who will receive only hrHPV-based screening. Strict surveillance of hrHPV persistent infection and occurrence of precancerous lesions will be conducted to estimate safety profiles at different screening intervals; participants will undergo diagnosis confirmation and treatment as necessary. The FASTER-Tlalpan Study will provide insights into new approaches of cervical cancer prevention programs. It will offer valuable information on potential benefits of combining HPV vaccination and hrHPV-based screening to safety extend screening intervals.