Role of Slc2a9 and Abcg2 Gene Polymorphisms in Origin of Hyperuricemia and Gout
Fadieieva, A.; Prystupa, L.; Pogorelova, O.; Kirichenko, N.; Dudchenko, I.
Georgian Medical News 252: 79-83
2016
ISSN/ISBN: 1512-0112 PMID: 27119840 Document Number: 690769
The polymorphisms V253I, Q126X, Q141K of SLC2A9 and ABCG2 genes were characterized. GCA и GTC haplotypes of Q126X and Q141K variants can be predictors of gout. The relationship of these polymorphisms with hyperuricaemia according to gender, metabolic syndrome components, with the response to allopurinol was analyzed. It has been established that Q141K polymorphism can directly modulate BCRP-mediated allopurinol and oxypurinol efflux, the K allele is associated with a lower reduction in serum uric acid in response to allopurinol treatment.