Two cases of sudden death due to pulmonary tumor thrombotic microangiopathy caused by occult gastric carcinoma
Ben Khelil, M.; Chkirbene, Y.; Azzouz, H.; Haouet, S.; Hamdoun, M.
Pathologica 108(4): 160-163
2016
ISSN/ISBN: 0031-2983 PMID: 28195256 Document Number: 690489
We present two cases of occult gastric carcinoma associated to a large pulmonary tumors thrombosis microangiopathy (PTTM). The first case is a 28 years-old man. He was dead due to a respiratory failure. Autopsy showed a whitish indurated mass invading the stomach wall. Histological findings showed a primary "signet ring" gastric adenocarcinoma with pulmonary carcinomatosis and multiple PTTM and a heart metastasis. The second case is a 24 years-old pregnant woman. The main symptoms were nausea and stomach discomfort and they were seen as pregnancy signs. She was dead because of respiratory failure, 10 hours after a vaginal delivery. Autopsy showed the absence of any cause of death related to the delivery and the presence of a whitish indurated mass in the stomach. Histological findings showed a primary "signet ring" gastric adenocarcinoma, with pulmonary carcinomatosis and multiple PTTM.