Perspectives of the Cell Therapy in Ophthalmology1. the Application of Stem Cells in the Regeneration of Damaged Surface of the Eye
Javorková, E.; Holáň, V.
Ceska a Slovenska Oftalmologie Casopis Ceske Oftalmologicke Spolecnosti a Slovenske Oftalmologicke Spolecnosti 72(1): 268-271
2016
ISSN/ISBN: 1211-9059 PMID: 27041281 Document Number: 690413
Regeneration of corneal epithelium is secured by a population of limbal stem cells (LSC), which are located in the basal part of the limbal epithelium. Deficiency in LSC leads to chronic inflammation, scarring and conjunctivization of cornea. Therapy of LSC deficiency consists in transplantation of limbal tissue, cultivated limbal epithelium or more recently in tranplantation of autologous cells including mesenchymal stem cells, oral mucosal epithelial cells or hair follicle-derived stem cells. A significant progress has been achieved in the field of cell therapy and also in the development of convenient scaffolds for the growth and transfer of cells on damaged cornea. ocular surface damage, stem cells, cell therapy.