Hereditary thrombophilia as a cause of recurrent transplant thromboses
Koester, B.H.; Köveker, G.B.; Pötsch, B.; Becker, H.D.
Der Chirurg; Zeitschrift für Alle Gebiete der Operativen Medizen 64(10): 809-812
1993
ISSN/ISBN: 0009-4722 PMID: 8269746 Document Number: 6904
We report a case of hereditary protein S and protein C deficiency which are a rare defects of the anti-coagulation-system. Protein S is a vitamin K dependent glycoprotein that functions as a cofactor to activated Protein C in the inactivation of coagulation factors V and VIIIa. A deficiency of these proteins caused by a genetic defect increase the risk of recurrent thrombosis at a younger age. Acquired decreases in protein S and C concentration have been reported in connection with age, sex, pregnancy and with oral anticonception. The higher risk for thrombotic diseases of patients with thrombophilia requires a sufficient treatment and prophylaxis, e.g. with fresh frozen plasma or a protein C concentrate.
Document emailed within 1 workday
