Which SSRIs most effectively treat depression in adolescents?
DeLucia, V.; Kelsberg, G.; Safranek, S.
Journal of Family Practice 65(9): 632-634
2016
ISSN/ISBN: 1533-7294 PMID: 27672691 Document Number: 690021
We don't know which selective serotonin reuptake inhibitors (SSRIs) are the most effective and safe because no studies have compared these antidepressants with each other. Three SSRI antidepressant medications--fluoxetine, sertraline, and escitalopram--produce modest improvements (about 5% to 10%) in standardized depression scores without a significant increase in the risk of suicide-related outcomes (suicidal behavior or ideation) in adolescent patients with major depression of moderate severity.