The Efficacy of Chitosan Dressing in Reducing Blood Loss for Harvest Site in Split Thickness Skin Graft: a Randomized Control Trial
Dilokhuttakarn, T.; Vilai, P.; Rungsinaporn, V.
Journal of the Medical Association of Thailand 99(Suppl 8): S19-S24
2016
ISSN/ISBN: 0125-2208 PMID: 29901373 Document Number: 689656
Split thickness skin grafting (STSG) is common procedure for covering soft tissue defects and causes bleeding due to large raw surface area. Chitosan is a biodegradable, non-toxic, complex carbohydrate derivative extracted from chitin found in the shells of crustaceous animals. Chitosan is a new local hemostatic dressing certified for external use. But there was no study which was conducted in the randomized control trial to prove the efficacy of chitosan in reducing blood loss for harvest site in split thickness skin graft. To compare the efficacy of chitosan dressing and standard dressings in reducing blood loss at STSG harvest site and observe its complications. A randomized control trial study to compare the efficacy of chitosan dressing and standard dressings in reducing blood loss at STSG harvest site was performed between June 2014 to August 2015 at HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakharinwirot University in Nakhon Nayok province. Demographic data, area of harvest site, blood loss, VAS score at the time of wound dressing and complications were recorded. Twenty patients with skin defect were randomly assigned into 2 groups (Chitosan group n = 10 and Standard Chitosan gauze dressing did not decrease blood loss from harvest sites of STSG compared with the standard dressing group and there was no serious complication associated with chitosan was detected.