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Eosinophilic granulomatosis with polyangiitis (EGPA) and allergic bronchopulmonary mycosis (ABPM)

Taniguchi, M.; Fukutomi, Y.

Nihon Rinsho. Japanese Journal of Clinical Medicine 74(10): 1721-1728

2016

ISSN/ISBN: 0047-1852
PMID: 30551287
Document Number: 689485
Eosinophilic granulomatosis with polyangiitis(EGPA) is characterized by ANCA-related small vessel vasculitis with granuloma formation and chronic eosinophilic airway inflammation including severe asthma and nasal polyposis. Allergic bronchopulmonary mycosis(ABPM) is characterized by asthma, central bronchiectasis, eosinophilic mucoid impaction, and fungal sensitization. The accurate diagnosis in early stages for these severe type of asthma is very important for good prognosis. Recent reports claimed that mepolizumab may be effective ad-on treatment for EGPA, and omalizumab is effective for ABPA.

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