New side effects of proton pump inhibitors; time for reflection?
De Wit, N.J.; Numans, M.E.
Nederlands Tijdschrift Voor Geneeskunde 160: D338
2016
ISSN/ISBN: 1876-8784 PMID: 27334088 Document Number: 689087
Large population studies published recently have revealed additional risks of chronic use of proton pump inhibitors (PPIs). Dementia and renal failure were reported as long-term follow-up side effects of chronic use, in addition to the previously known increased risk for various infections, osteoporosis and metabolic disturbances. In the light of ongoing over-prescription of PPIs, this should lead to reconsideration of individual indications.