The effects of intraperitoneal chemotherapeutic agents on adhesion formation
Akgol, G.; Yildiz, C.; Karakus, S.; Koc, M.; Dogan, M.; Turan, K.; Karadayi, K.
European Journal of Gynaecological Oncology 37(6): 781-785
2016
ISSN/ISBN: 0392-2936 PMID: 29943920 Document Number: 688840
Intra-abdominal adhesions are a major complication of healing. Furthermore these adhesions may cause morbidity and sometimes mortality for patients, and also are a financial burden to the health system. Cecum abrasion was performed in all rats and solutions containing saline to group 1, 5-fluorouracil to group 2, cisplatin to group 3, paclitaxel to the group 4, and mitomycin-C were administered into the abdomen of the groups, respectively. The intra-abdominal adhesions were scored after the macroscopic evaluation. Among the chemotherapeutic drugs, paclitaxel significantly increases occurring of intra-abdominal adhesions in comparison with the control group and the other drugs according to the evaluation of scoring and statistical studies. It is suggested to use the drugs which have a proven anti-adhesion feature or barriers to the patients who are going to be applied intraperitoneal chemotherapy with paclitaxel.