Construction and anti-tumor efficacy of a pentameric peptide vaccine that targets S100A8
Qiu, L.-c.; Lu, W.-g.; Li, R.-x.
Yao Xue Xue Bao 51(2): 294-301
2016
ISSN/ISBN: 0513-4870 PMID: 29856584 Document Number: 688656
Myeloid-derived suppressor cells(MDSC) play critical roles in immune escape of tumor. We hypothesized that elimination of tumor-induced MDSCs might help to block tumor growth. Therefore, we constructed a cholera toxin B based peptide vaccine that targets a MDSC surface marker S100A8. Immunized BALB/c mice with CTB-S100A8 plus aluminum hydroxide induced high titers of anti-S100A8 antibodies and reduced tumor burden significantly in 4T1 mice model. We also found the vaccination led to significant reduction of tumor-induced monocytic MDSC(M-MDSC), with no effect on innate MDSCs, dendritic cell(DC) and macrophage(Mφ), demonstrating that targeting tumor-induced MDSC may be a promising approach in cancer immunotherapy.