Female Steroid Hormones - Modulators of Immune Response to Genital Chlamydia Trachomatis Infection
Kovachev, E.; Ivanov, S.; Bechev, B.; Angelova, M.; Grueva, E.; Kolev, N.; Ivanova, V.
Akusherstvo i Ginekologiia 55(4): 3-8
2016
ISSN/ISBN: 0324-0959 PMID: 29370486 Document Number: 688495
In the recent years according to WHO, genital chlamydia is the mos't common sexually transmitted infection. Chlamydia Trachomatis is an intracellular parasite which target are the tubular epithelial cells of the urethra, endocervix, endometrium, endosalpinx, conjunctiva, synovial lining of the joints, Glisson's capsule of the liver Our study, as well as some international researches, shows that in the cases of genital chlamydia there are changes in the ovarian hormones (estradiol and progesterone), their impact on the immune system and their importance for the development and the complications of the infection with Chlamydia trachomatis. The physiological level of the steroid hormones in its turn contributes for the normalization of the local immunity and reduces the possibility of recurrences.