Prevention and treatment for intractable infectious diseases through the iPSC-based technology: status quo and perspective
Wakao, H.; Sugimoto, C.
Nihon Rinsho. Japanese Journal of Clinical Medicine 74(12): 2064-2069
2016
ISSN/ISBN: 0047-1852 PMID: 30550668 Document Number: 688082
Nowadays, antibiotic resistance is a serious global health concern, for it is observed every- where on the earth. While antibiotic is effective for controlling pathogens, an inappropriate use of the antibiotic leads to antibiotic resistance. Given that the ability to develop novel anti- biotics is quite limited, a new strategy must be developed to fight against it. Mucosal- associated invariant T cells (MAITs) belong to a family of the innate-like T cells that bridges the gap between the innate and the adaptive immunity. We have generated iPSCs from MAITs and redifferentiated MAITs from the iPSCs. These MAITs exerted anti- mycobacterial activity in mice. Advent of such cells will pave the way to exploit a novel arsen- al against antibiotic resistance.