Pregnancy-associated osteoporosis (PAO) with multiple vertebral fragility fractures: diagnosis and treatment in a young primigravid woman
Pola, E.; Colangelo, D.; Nasto, L.A.; Pambianco, V.; Autore, G.; Formica, V.M.; Maccauro, G.
Journal of Biological Regulators and Homeostatic Agents 30(4 Suppl 1: 153-158
2016
ISSN/ISBN: 0393-974X PMID: 28002913 Document Number: 687889
PAO is an uncommon condition affecting pregnant women during last trimester or early post-delivery period; it is often asymptomatic or presents with pain related to some acute fragility fractures. The diagnosis is often delayed or missed, the etiology remains unknown and no guidelines about treatment have been published. We present one case of PAO in a 33-year-old primigravid woman presenting acute worsening back pain. Our patient was treated with a TLSO brace, oral 25 (OH)-vitamin D supplementation and Teriparatide for 6 months. A short review of the literature has been included and useful advice about how to suspect and diagnose this uncommon disease were given in order to recognize and treat such a debilitating and severe condition for young mothers as best as possible, based on the available scientific evidences.