Oral Cancer Chernoprevention: Current Status and Future Direction
Messadi, D.V.; Sato, K.
Journal of the California Dental Association 44(2): 101-111
2016
ISSN/ISBN: 1043-2256 PMID: 26930753 Document Number: 687724
The aim of this study is to review the current status of cancer chemoprevention and its effectiveness in treatment of oral premalignant lesions and prevention of their progression to oral cancer. The challenges encountered in the different oral cancer chemoprevention clinical trials, including lack of surrogate endpoints, reversal of histologic premalignant changes as study endpoints, tobacco use, human papillomavirus, delivery system, adverse effects and risk of bias in clinical studies, are presented.