The characteristics of the new indices of hemogram under liver cirrhosis
Baranovskaya, I.B.; Zentsova, O.A.; Sysoieva, I.P.
Klinicheskaia Laboratornaia Diagnostika 61(10): 705-710
2016
ISSN/ISBN: 0869-2084 PMID: 30615334 Document Number: 687701
The diagnostic significance of new indices of hemogram under liver cirrhosis associated with thrombocytopenia (n=64) was analyzed. It is established that in comparison with control group the patients with cirrhosis are characterized by statistically valuable increasing of content of immature cells of three germs of hematopoiesis: reticulocytes up to 1.99±1.54%, granulocytes up to 0.44±0.77%, immature thrombocytes up to 3.23±1.7%. Under liver pathology, the following occurrences are detected: "left shift" of reticulocyte and leukocyte formula; reliable decreasing of content of hemoglobin in reticulocytes. The increasing of both of content of fragmentary erythrocytes (Frg) up to 0.83±1.21% and level of delta-hemoglobin (D-He>4 ng) were interpreted as additional markers of hemolysis. At that, negative values of delta-hemoglobin (D-He<0 ng) in 6.3% of patients are associated with concomitant inflammation. As a result of study, new data was obtained concerning characteristics of hematopoiesis under liver cirrhosis increasing quality of laboratory monitoring of patients with the given pathology.