Diabetes-related dementia
Hanyu, H.
Nihon Rinsho. Japanese Journal of Clinical Medicine 74(3): 495-498
2016
ISSN/ISBN: 0047-1852 PMID: 27025093 Document Number: 687665
Type 2 diabetes mellitus (DM) has been shown to increase the risk of cognitive decline and dementia, such as Alzheimer's disease (AD) and vascular dementia. Among subjects with dementia and DM, there is a dementia subgroup with characteristics predominantly associated with DM-related metabolic abnormalities rather than AD or vascular pathology. The subgroup was characterized by old age, high hemoglobin A1c level, long duration of diabetes, high frequency of insulin therapy, low frequency of apolipoprotein E4 carrier status, less severe medial temporal lobe atrophy, impaired attention but less impaired word recall, and slower progression of cognitive impairment, referred to as "diabetes-related dementia". The identification of diabetes-related dementia may be necessary for considering an appropriate therapy and prevention in clinical practice.