Effects of ethinyl estradiol-containing oral contraception and other factors on body composition and muscle strength among young healthy females in Finland-A cross-sectional study
Suuronen, J.; Sjöblom, S.; Tuppurainen, M.; Honkanen, R.; Rikkonen, T.; Kröger, H.; Sirola, J.
European Journal of Obstetrics Gynecology and Reproductive Biology 232: 75-81
2019
ISSN/ISBN: 0301-2115 PMID: 30502591 DOI: 10.1016/j.ejogrb.2018.11.015Document Number: 687630
The aim of this cross-sectional study was to determine the association of hormonal contraception and other life-style factors and habits affecting body composition (BC) and muscle strength. We measured the body composition of 400 healthy Finnish women (aged 20-40 years) using total body dual energy x-ray absorptiometry (TB-DXA) as well as grip strength (GS ) and fat-%. Participants filled out a questionnaire concerning life-style factors and habits: hormonal contraception, physical activity, alcohol consumption, age, pregnancies, smoking and self-assessed health that were also adjusting factors in the covariate model. We investigated the effects of hormonal contraception and other life-style factors and habits on body composition and muscle strength using AN(C)OVA in the analyses. Women using hormonal contraception with the combination of ethinyl estradiol + progestogen had significantly lower mean ASM (18.0), RSMI (6.5), TLM (40.8) (p < 0.01) and GS (34.6) (p < 0.001) compared to the women not using hormonal contraception with mean values of ASM (18.8), RSMI (6.7), TLM (42.6) and GS (36.9). After adjustment ASM (18.3), SMI (64.3), GS (35.2) (p < 0.05), RSMI (6.6) and TLM (41.2) (p < 0.01) were significantly lower and fat-% (31.4) higher (p < 0.05) compared to women not using hormonal contraception with mean values of ASM (19.0), SMI (66.1), GS (36.7), RSMI (6.8), TLM (42.7) and fat-% (29.8). Use of ethinyl estradiol + progestogen-containing hormonal contraception may have negative association with muscle mass and strength.