Hb G Makassar (beta 6:Glu-Ala) in a Thai family
Sangkitporn, S.; Rerkamnuaychoke, B.; Sangkitporn, S.; Mitrakul, C.; Sutivigit, Y.
Journal of the Medical Association of Thailand 85(5): 577-582
2002
ISSN/ISBN: 0125-2208 PMID: 12188388 Document Number: 6875
Hemoglobin G Makassar was identified in a family of Thai origin, which was found to share identical properties with hemoglobin S in routine hemoglobin separation both by cellulose acetate electrophoresis and cation-exchange HPLC. It is, therefore, subjects with hemoglobin G Makassar and hemoglobin S who may sometimes be mistakenly identified for each other. In this study, identification of hemoglobin G Makassar was achieved by DNA sequence analysis, which revealed a single nucleotide substitution GAG-->GCG at codon 6 of the beta-globin gene. The hemoglobin variant was hemoglobin G Makassar [beta 6:Glu-->Ala]. This is the first report of hemoglobin G Makassar in Thailand.
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