Valproic Acid and Hepatic Steatosis: A Possible Link? About a Case Report
Mnif, L.; Sellami, R.; Masmoudi, J.
Psychopharmacology Bulletin 46(2): 59-62
2016
ISSN/ISBN: 0048-5764 PMID: 27738381 Document Number: 687389
Valproic acid is a mood-stabilizing anticonvulsant. Hepatic injuries are among the occasionally observed adverse effects of this medication. We present the case of a 47-year-old man who had bipolar disorder for ten years and treated with valproic acid. He demonstrated elevated serum aminotransferases and ultrasonography revealed that hepatomegaly was suggestive of hepatic steatosis. This case report stresses the importance of a complete drug history and the need for clinicians to be aware of the delayed onset of hepatic injuries.