Clinical bystander effect exerted by allergen immunotherapy: a hypothesis
Ciprandi, G.
European Annals of Allergy and Clinical Immunology 47(2): 62-63
2015
ISSN/ISBN: 1764-1489 PMID: 25781197 Document Number: 685576
Allergen Immunotherapy (AIT) is able to restore a physiological Th1 response and Tregs function. This effect is allergen-specific, even though it has been reported that it may also be non-specific, such as also extended to allergens not used in AIT. This immunological phenomenon may also be of clinical nature. This case report shows that a poly-allergic patient, successfully treated with Parietaria extract, also achieved a clinical tolerance towards other causal allergens, such as mites and cat. Of course, this was an anecdote, but it is reasonable to prospect the hypothesis that a bystander clinical effect may be observed during AIT in poly-allergic patients.