HelpDesk answers: is it safe to add long-acting β-2 agonists to inhaled corticosteroids in patients with persistent asthma?
Townsend, L.; Madlon-Kay, D.J.
Journal of Family Practice 64(6): 370-371
2015
ISSN/ISBN: 1533-7294 PMID: 26172630 Document Number: 685059
Possibly. Long-acting β-2 agonists (LABAs) used in combination with inhaled corticosteroids (ICS) don't appear to increase all-cause mortality or serious adverse events in patients with persistent asthma compared with ICS alone. Studies showing an increase in catastrophic events had serious methodologic issues. A large surveillance study is ongoing.
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