KPC and VIM producing Enterobacter cloacae strain from a hospital in northeastern Venezuela
Martínez, D.; Marcano, D.; Rodulfo, H.; Salgado, N.; Cuaical, N.; Rodriguez, L.; Caña, L.; Medina, B.; Guzman, M.; De Donato, M.
Investigacion Clinica 56(2): 182-187
2015
ISSN/ISBN: 0535-5133 PMID: 26299058 Document Number: 684860
An 83-year-old male patient is admitted to the central hospital in Cumana, Venezuela with severe urinary infection, history of hospitalizaions and prolonged antimicrobial treatments. A strain of Enterobacter cloacae was isolated showing resistance to multiple types of antibiotics (only sensitive to gentamicin), with phenotype of serine- and metallo-carbapenemases. Both, bla(VIM-2) and bla(KPC) genes were detected in the isolate. This is the first report of an Enterobacteriaceae species producing both KPC carbapenemase and VIM metallo carbapenemase in Venezuela. This finding has a great clinical and epidemiological impact in the region, because of the feasibility of transferring these genes, through mobile elements to other strains of Enterobacter and to other infection-causing species of bacteria.